Most times, how comfortable your baby is depends entirely on the state of his diaper. So choose carefully. The best thing to do is to use a combination of store-bought diapers and soft, cotton homemade ones. Disposable diapers are made of synthetic material and used over a long period may give your baby diaper rash, so use when you’re out or at night to ensure that your baby gets his full night’s undisturbed sleep. During the day, use the light, cotton homemade diapers that let his skin breathe.